Course Identification

Tumor immunology
20183302

Lecturers and Teaching Assistants

Dr. Rony Dahan
N/A

Course Schedule and Location

2018
Second Semester
Sunday, 14:15 - 16:00, FGS, Rm 5
18/03/2018

Field of Study, Course Type and Credit Points

Life Sciences: Seminar; Elective; 2.00 points
Life Sciences (Systems Biology Track): 2.00 points
Life Sciences (Molecular and Cellular Neuroscience Track): 2.00 points

Comments

N/A

Prerequisites

No

Restrictions

30

Language of Instruction

English

Attendance and participation

Obligatory

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

50%
50%

Evaluation Type

Seminar

Scheduled date 1

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-
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Estimated Weekly Independent Workload (in hours)

N/A

Syllabus

This course will deal with the cellular and molecular basis of immunity to Cancer. In particular: Immunosurveillance, cellular and humoral immunity and their regulation, Immune escape mechanisms, immune suppressive mechanism, Tumor Associated Antigens (TAAs) detected by Anibodys, TAAs detected by CTL, Active vaccination approaches including whole cell gene modified tumor cells vaccines, whole cell cytokine gene modified tumor cells vaccines, Dendritic cell vaccines, peptide vaccines, protein vaccines, RNA vaccines, DNA vaccines, viral delivery systems including Vaccinia, retroviruses, adenoviruses and others. Passive vaccination approaches, including Antibodies, immunotoxins, bispecific Antibodies, Antibodies to inhibitory and stimulatory check points, Tumor infiltrated lymphocytes (TILs), Natural killer cells (NK), Lymphokine activated killer cells (LAK), Engineered Lymphocytes, CAR transduced Lymphocytes.

Learning Outcomes

Upon successful completion of this course students should be be able to:

  1. Demonstrate proficiency in tumor-immune system interactions: Tumor metastases immunosurveillance, T and B cell responses to cancer, immune supressive mechanism, therapeutic strategies, monoclonal antibodies, gene therapy, tumor associated antigens, anti tumor vaccines, immune monitoring in cancer.

Reading List

Each participant will present 1-2 papers in ~45 minutes. The students will also be required to read before each lesson the papers to be presented so we can have an in-depth discussion.

Website

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