Introduction to Neuroscience, Course syllabus, 2019-2020:
1) Introduction: The structure and basic function of Neurons. (Lampl 4/11/2019)
2) The Ionic basis of the resting potential: Nernst equation, Goldman equation. Pumps. (Lampl, 11/11/2019)
3) Passive membrane properties. Equivalent electrical circuit. Cable theory: derivation, solutions, and implications for neuronal function. (Lampl, 18/11/2019)
4) Active membrane properties and the action potential. (Lampl, 25/11/2019)
5) Hodgkin-Huxley experiments and model. (Lampl, 2/12/2019)
6) Diversity of Ion Channels: Permeability, electrophysiology, single-channel recordings, channel structure. Ligand-gated ion channels (glutamate, GABA, glycine, serotonin, calcium…). Basic pharmacological tools. Clinical aspects of channel dysfunction. (Reuveny , 9/12/2019)
7) Synaptic Transmission - General overview. Measurements and modeling of synaptic transmission: The reversal potential, synaptic conductance, excitation and inhibition, Model of ionotropic and ligand-gated synaptic transmission. Short-term synaptic dynamics (synaptic depression and facilitation). Temporal and spatial synaptic integration. Electrical synapses. (Lampl, 16/12/2019)
8) Synaptic transmission: Transmitter release, vesicles, quantal release, presynaptic molecular mechanisms. (Reuveny, 23/12/2019)
9) Receptors: Molecular cascades, pharmacological manipulations. (Reuveny , 30/12/2019)
10) Neuronal Plasticity: NMDA versus AMPA receptors; Long-term potentiation (LTP) and beyond. (Segal, 6/1/2020)
11) Modern electrophysiological and optical recording techniques in the field of cellular and synaptic physiology. (Lampl, 13/1/2020).
12) Advanced topics in cellular electrophysiology & Exam Rehearsal. (Lampl, 20/1/2020).