Course Identification

Contemporary Neuroimmunology and Psycho-Neuroimmunology
20223172

Lecturers and Teaching Assistants

Prof. Michal Schwartz , Prof. Asya Rolls, Dr. Stefano Suzzi
Tommaso Croese

Course Schedule and Location

2022
Second Semester
Monday, 11:15 - 13:00, FGS, Rm C
28/03/2022
19/08/2022

Field of Study, Course Type and Credit Points

Life Sciences: Lecture; Elective; Regular; 1.00 points
Life Sciences (Molecular and Cellular Neuroscience Track): Lecture; 1.00 points
Life Sciences (Brain Sciences: Systems, Computational and Cognitive Neuroscience Track): Lecture; 1.00 points

Comments

Courses dates:
28.3
3.4
11.4
25.4
2.5
9.5
23.5
6.6
20.6
4.7

Prerequisites

N/A

Restrictions

100

Language of Instruction

English

Attendance and participation

Obligatory

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

100%

Evaluation Type

Final assignment

Scheduled date 1

N/A
N/A
-
N/A

Estimated Weekly Independent Workload (in hours)

1

Syllabus

Brief summary of items that will be covered in the course:

1. General introduction to the relationships between the brain and the blood: The blood brain barrier and blood cerebrospinal fluid barrier ? structural and functional relationships.

2. General introduction to the brain as an immune privileged site.

3. Brief summary of the cellular composition of the brain and the interplay among the interacting cell types.

4. The diversity of innate immunity within and outside the brain, during ontogeny and in adulthood.

5. Cellular and molecular aspects of central nervous system regeneration processes

6. Life-long cell renewal in the adult brain- neurogenesis, and gliogenesis: Mechanisms of control, and implications for cognition, coping with stress, and depression.

7. The role of immunity in brain plasticity and repair

8. Immunity and cell renewal.

9. Immunity and resilience to stress.

10. The role of the immune system in aging and dementia; prospect of harnessing the immune system to help the brain

Contemporary Neuroimmunology - Course schedule

 Introduction

 Neurogenesis
Central nervous system mechanisms of repair

 Immune cells in spinal cord repair, and in Alzheimer?s disease

 Stress and depression

 The functional role of stem cells in the brain (Dr. Yaniv Ziv, The Weizmann)

 ALS, why it is so devastating?

 Immune cells in neurodevelopmental diseases (Rett and Schizophrenia)

 Brain aging, and age-related dementia

Learning Outcomes

Upon successful completion of the course students will be able to:

[1] Demonstrate understanding of Brain immunology.

[2] Discuss the role of the immune system in brain plasticity (cell renewal from neural stem cells, cognition and coping with stress) and what gets awry in brain aging and dementia.

[3] Demonstrate understanding of basic aspects of brain immunity under stress, posttraumatic stress disorders and depression.

[5] Have basic aspect of central nervous system healing and the missing link in neurodegenerative diseases such as Alzheimer?s diseases and ALS.

Reading List

N/A

Website

N/A