Course Identification

Protein Structure and Function 1
20242311

Lecturers and Teaching Assistants

Prof. Deborah Fass, Prof. Ron Diskin
Ariel Tennenhouse

Course Schedule and Location

2024
First Semester
Tuesday, 09:15 - 11:00, Wolfson Auditorium

Tutorials
Wednesday, 16:00 - 17:00, FGS, Rm C
12/12/2023
20/02/2024

Field of Study, Course Type and Credit Points

Chemical Sciences: Lecture; Core; 3.00 points
Life Sciences: Core; 3.00 points

Comments

This course will be held by hybrid learning.
The course will take place at Wolfson Auditorium except for 05/12-FGS Rm B

Prerequisites

No

Restrictions

200

Language of Instruction

English

Attendance and participation

Obligatory

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

50%
50%

Evaluation Type

Examination

Scheduled date 1

N/A
N/A
-
N/A

Scheduled date 2

N/A
N/A
-
N/A

Estimated Weekly Independent Workload (in hours)

4

Syllabus

Lecture 1 (24/10/23) DF
Course Introduction

Protein primary structure: physical-chemical composition of proteins

 

31/10/23

No class—Israeli municipal elections

 

Lecture 2 (7/11/23) DF
Protein secondary structure: helices, sheets, and beyond!

 

Lecture 3 (14/11/23) RD
Tertiary structure: folding motifs, topology, evolution of protein folds

 

Lecture 4 (21/11/23) RD
Principles, practices, challenges, and recent revolutions in protein structure determination

 

Lecture 5 (28/11/23) RD
Protein structure determination (continued), computational protein fold prediction

 

Lecture 6 (5/12/23) DF
Quaternary structure: protein oligomerization

 

Lecture 7 (12/12/23) DF

Quaternary structure: polymerization and protein pathologies


Lecture 8 (19/12/23) DF
Protein thermodynamics

 

Lecture 9 (26/12/23) RD
Protein-protein interactions

 

Lecture 10 (2/1/24) DF
Protein folding, conformational changes, and dynamics in protein function

 

Lecture 11 (9/1/24) RD

Enzymes

 

Lecture 12 (16/1/24) DF
Membrane proteins

 

Lecture 13 (23/1/24) RD
Molecular Machines

 

Learning Outcomes

Upon successful completion of this course students should be able to understand why proteins fold and be familiar with the factors influencing protein folding, interaction, and function. They should be able to critically evaluate contemporary literature reporting data and analysis of protein structure determination. They should be inspired to carry out research in the fields of protein biochemistry and structural biology!

Reading List

N/A

Website

N/A