Course Identification

Title:

Finding a needle in the haystack: A traveler guide to the small molecule?s multiple universes (multiverse).

Code:

20223352

Lecturers and Teaching Assistants

Lecturers:

Prof. Ami Navon

TA's:

N/A

Course Schedule and Location

Year:

2022

Semester:

Second Semester

When / Where:

Thursday, 14:15 - 16:00, WSoS, Rm B

First Lecture:

31/03/2022

End date:

19/08/2022

Field of Study, Course Type and Credit Points

Life Sciences: Lecture; Elective; Regular; 2.00 points
Chemical Sciences: Lecture; Elective; Regular; 2.00 points
Life Sciences (Molecular and Cellular Neuroscience Track): Lecture; Elective; Regular; 2.00 points

Comments

Understand the power of small molecules, the challenge of screening an infinite number of small molecule and finally to synthesize the chosen molecule (each group of students will fish and synthesize a small molecule to a selected target).

Prerequisites

No

Restrictions

Participants:

35

Language of Instruction

English

Attendance and participation

Expected and Recommended

Grade Type

Pass / Fail

Grade Breakdown (in %)

Seminar:

50%

Final:

50%

Evaluation Type

Final assignment

Scheduled date 1

Date / due date

N/A

Location

N/A

Time

-

Remarks

N/A

Estimated Weekly Independent Workload (in hours)

N/A

Syllabus

The major intent of the course is to provide basic tool to select protein/complexes suitable to be targeted by small molecules. The basic principle of virtual screening, lead selection and optimization in the context of medicinal chemistry will be visited. Chosen examples will be synthesis and evaluated as time permit. Students will become familiar with the leading platform and methodologies for the generation, screening and evaluating large cohort of virtual libraries.

Learning Outcomes

Upon successful completion of the course the students will be able to:

Choose “promising” protein targets.

Define suitable binding pockets for small molecules binding

Search the virtual space for candidates

Dock and rank candidate molecules

Tools to optimize lead candidate

Synthesis related considerations

From the drawing board to the chemical hood

Reading List

Will be distributed on the first meeting

Website

N/A