Course Identification

Cell Death in Health and Disease
20253292

Lecturers and Teaching Assistants

Prof. Eli Arama, Prof. Adi Kimchi, Prof. Moshe Oren, Prof. David Wallach, Prof. Atan Gross, Prof. Valery Krizhanovsky, Prof. Avraham Yaron
Dr. Tslil Braun

Course Schedule and Location

2025
Second Semester
Tuesday, 09:15 - 11:00, Belfer, Botnar Auditorium
25/03/2025
01/07/2025

Field of Study, Course Type and Credit Points

Life Sciences: Lecture; Elective; Regular; 2.50 points

Comments

On June 24th, 2025, the course will take place at WSoS Room C

Students are required to hand a short assignment after the 2nd lecture of each lecturer (total of 7 assignments). Students who hand all the assignments will pass as long as they are made in good faith. There will be no grades, only pass/fail, pending that all the assignments are handed (and pass).

Prerequisites

No

Restrictions

120

Language of Instruction

English

Attendance and participation

Expected and Recommended

Grade Type

Pass / Fail

Grade Breakdown (in %)

100%

Evaluation Type

No final exam or assignment

Scheduled date 1

N/A
N/A
-
N/A

Estimated Weekly Independent Workload (in hours)

1

Syllabus

Semester 2 (23/03/2025 - 04/07/2025)

Cell death in health and disease 2025 (Tuesdays 9:15-11:00)

Botnar auditorium except for June 24 (WSoS room C)

25.3     BCL-2 proteins: regulators of life versus death decisions (Atan Gross)

1.4       The metabolic side of cell death (Atan Gross)

8.4       The TNF family, the extrinsic apoptotic pathway, necroptosis and pyroptosis – Part I (David Wallach)

15.4     Passover

22.4     The TNF family, the extrinsic apoptotic pathway, necroptosis and pyroptosis – Part II (David Wallach)

29.4     p53: master regulator of life, death and cancer – Part I (Moshe Oren)

6.5       p53: master regulator of life, death and cancer – Part II (Moshe Oren)

13.5     The genetics of apoptosis: from large screens in model organisms to mechanistic understanding (Eli Arama)

20.5   Death without caspases and caspases without death in development (Eli Arama)

27.5     Autophagy: a mechanistic view of a basic biological process that controls life and death decisions of a cell – Part I (Adi Kimchi) 

3.6       Autophagy: a mechanistic view of a basic biological process that controls life and death decisions of a cell – Part II (Adi Kimchi)

10.6     The regulation of neurodevelopmental cell death (Avraham Yaron)

17.6     Sculpting the nervous system by non-apoptotic activities of the cell death system (Avraham Yaron)

24.6     Cellular senescence is an anti-cell death mechanism (Valery Krizhanovsky)

1.7       Do senescent cells promote organismal death? (Valery Krizhanovsky)

 

Learning Outcomes

Upon successful completion of this course students should be able to:

  1. Apply the knowledge gained in this course to performing research in fields of cell death, autophagy, senescence, and non-lethal functions of caspases.
  2. Develop novel hypotheses and avenues of research related to biology of cell death.
  3. Gain more insight into the process of performing science in academia and require skills for developing into a successful scientist.

Reading List

N/A

Website

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