Course Identification

Title:

Cell Death in Health and Disease

Code:

20253292

Lecturers and Teaching Assistants

Lecturers:

Prof. Eli Arama, Prof. Adi Kimchi, Prof. Moshe Oren, Prof. David Wallach, Prof. Atan Gross, Prof. Valery Krizhanovsky, Prof. Avraham Yaron

TA's:

N/A

Course Schedule and Location

Year:

2025

Semester:

Second Semester

When / Where:

Tuesday, 09:15 - 11:00, Wolfson Auditorium

First Lecture:

25/03/2025

End date:

01/07/2025

Field of Study, Course Type and Credit Points

Life Sciences: Lecture; Elective; Regular; 2.50 points

Comments

On June 24th, 2025, the course will take place in FGS Room C

Students are required to hand a short assignment after the 2nd lecture of each lecturer (total of 7 assignments). Students who hand all the assignments will pass as long as they are made in good faith. There will be no grades, only pass/fail, pending that all the assignments are handed (and pass).

Prerequisites

No

Restrictions

Participants:

120

Language of Instruction

English

Attendance and participation

Expected and Recommended

Grade Type

Pass / Fail

Grade Breakdown (in %)

Assignments:

100%

Evaluation Type

No final exam or assignment

Scheduled date 1

Date / due date

N/A

Location

N/A

Time

-

Remarks

N/A

Estimated Weekly Independent Workload (in hours)

1

Syllabus

25.3 BCL-2 proteins: regulators of life versus death decisions (Atan Gross)

1.4 The metabolic side of cell death (Atan Gross)

8.4 The genetics of apoptosis: from large screens in model organisms to mechanistic understanding (Eli Arama)

15.4 Passover

22.4 Death without caspases and caspases without death in development (Eli Arama)

29.4 The role of cell death in immune defense and pathology: The TNF family, the extrinsic apoptotic pathway and necroptosis – Part I (David Wallach)

6.5 The role of cell death in immune defense and pathology: The TNF family, the extrinsic apoptotic pathway and necroptosis – Part II (David Wallach)

20.5 p53: master regulator of life, death and cancer – Part I (Moshe Oren)

27.5 p53: master regulator of life, death and cancer – Part II (Moshe Oren)

3.6 Autophagy: a mechanistic view of a basic biological process that controls life and death decisions of a cell – Part I (Adi Kimchi)

10.6 Autophagy: a mechanistic view of a basic biological process that controls life and death decisions of a cell – Part II (Adi Kimchi)

17.6 Cellular senescence is an anti-cell death mechanism (Valery Krizhanovsky)

24.6 Do senescent cells promote organismal death? (Valery Krizhanovsky)

1.7 The regulation of neurodevelopmental cell death (Avraham Yaron)

Learning Outcomes

Upon successful completion of this course students should be able to:

Apply the knowledge gained in this course to performing research in fields of cell death, autophagy, senescence, and non-lethal functions of caspases.
Develop novel hypotheses and avenues of research related to biology of cell death.
Gain more insight into the process of performing science in academia and require skills for developing into a successful scientist.

Reading List

N/A

Website

N/A