Course Identification

From biomolecules to biosystems
20251112

Lecturers and Teaching Assistants

Prof. Joel Stavans
N/A

Course Schedule and Location

2025
Second Semester
Tuesday, 14:15 - 16:00, Drori Auditorium
Wednesday, 14:15 - 16:00, Drori Auditorium
25/03/2025
02/07/2025

Field of Study, Course Type and Credit Points

Physical Sciences: Regular; 4.00 points
Life Sciences: Lecture; 2.00 points
Life Sciences (Computational and Systems Biology Track): Lecture; 2.00 points
Mathematics and Computer Science: Lecture; 2.00 points

Comments

N/A

Prerequisites

No

Restrictions

30

Language of Instruction

English

Attendance and participation

Obligatory

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

30%
45%
25%

Evaluation Type

Final assignment

Scheduled date 1

N/A
N/A
-
N/A

Estimated Weekly Independent Workload (in hours)

2

Syllabus

1.     Physics of biological polymers          

2.     Entropic effects: macromolecular crowding, depletion interactions

3.     Elements of the physics of membranes

4.     DNA and RNA

            Structure

            Basic processes: replication, transcription, translation, recombination        

5.     Accuracy of biological information processing: proofreading schemes

6.     Proteins

              Structure

              Folding

7.     Proteins as molecular machines

              Enzymes, Michaelis-Menten description

              Cooperative interactions

8.     Control of gene expression

              Transcription factors, DNA looping

               Small RNA in bacteria

               RNA interference

6.     Physics of molecular motors

             Statistical mechanics of barrier crossing by thermal activation

             Fokker-Planck formalism

7.      Stochastic phenomena in cells

            Target search by transcription factors

            Signal to noise in signaling pathways

Sensing by receptors

8.     Networks

             Basics of control theory (feedback, feedforward loops)

             Architectures

              Noise

             Model networks

 Regulation of gene expression by RNA

9.    Elements of Evolution

              The Eigen model

10.  Elements of Development

            Activator-inhibitor models, Turing instability

11.  Photosynthesis

12.  Topics in Ecology

            Logistic growth (RG analysis of period doubling)

            Lotka Volterra

            Allee effects

            SIR epidemics model

13.   Active matter

Learning Outcomes

The students will be exposed to a wide variety of topics of current interest in quantitative biology and biophysics

Reading List

N/A

Website

N/A