Course Identification

Basic course in immunology is mandatory 

Meeting 1: Introduction to the course. Course assignments, key questions. Part1-A Node Between the Immune Cells and Their Environment:  Immune cells – Adipocytes interaction in adipose tissue in leanness and in obesity. Inflammation: a signature feature of metabolic disorders linked to obesity. White adipose tissue immune cells in obesity and metabolic diseases.

Meting 2: Adipose tissue macrophages in leanness and obesity. Adipocyte-derived exosomes interaction wu immune cell interaction.

Meeting 3: T regulatory cells in adipose tissue and their function in maintaining metabolic homeostasis. 

Meeting 4: immune cells interaction with brown adipose tissues. Sympathetic neurons associated with immune cells and brown adipose macrophages control of tissue innervation and energy expenditure. 

Meeting 5: Part2-A Node Between the Immune Cells and Their Environment:  Immune cells – gut tissue interactions. The gastro-intestinal tract is inhabited by commensal microorganisms
that exist in a mutualistic relationship with the host. Immune cells at the intestinal epithelial border. The influence of single commensal bacterium on intestinal TH17 cells. 

Meeting 6: The Interaction of Treg cells with the microbiome. Identification of T cells against the bacteria of a well-defined complex community in the gut.

Meeting 7: Induction of Tregs by RORgT+ Cells leads to Treg induction and prevents immune response to harmless bacteria. 

Meeting 8: Microbial metabolites, short chain fatty acids, regulate the differentiation and function of colonic Treg cell homeostasis. 

Meeting 9: Microbial metabolites, Bile acids regulate the function of Th17 and Treg cells and their contribution to inflammatory response. 

Meeting 10: Immunoglobulin A coating and bacterial interaction in health and in inflammatory bowel diseases. 

Meeting 11: The gut commensal microbiome in health and disease and their interaction with immune cells. 

The students will gain knowledge through research studies in the field that focus on how immune cells interact with the environment. These studies will cover various aspects, such as how the immune system responds to an excessive intake of food, leading to obesity and metabolic diseases. The students will also be introduced to the concept of immunometabolism.

Another important topic to explore is the interaction between the gut microbiome and the host, and how this interaction affects both health and diseases.

Lastly, the students will be taught about the immune system's ability to sense the environment and the different mechanisms that underlie this sensing process.

Will be determined