Course Identification

Exploring Topics in Protein-Nucleic Acid Interactions: From Binding Specificity to Cellular Roles.
20252132

Lecturers and Teaching Assistants

Dr. Ariel Afek, Dr. Naama Kessler
Tamir Avioz

Course Schedule and Location

2025
Second Semester
Monday, 09:15 - 11:00, WSoS, Rm A
02/04/2025
30/06/2025

Field of Study, Course Type and Credit Points

Chemical Sciences: Lecture; Elective; 2.00 points

Comments

The first lesson will be a one-time occurrence on Wednesday, April 2nd between 9:15-11:00 at WSoS, Rm B

Prerequisites

Basic knowledge of molecular biology

Restrictions

25

Language of Instruction

English

Attendance and participation

Required in at least 80% of the lectures

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

40%
30%
30%
The evaluation will be based on quizzes, assignments, and class discussions

Evaluation Type

No final exam or assignment

Scheduled date 1

N/A
N/A
-
N/A

Estimated Weekly Independent Workload (in hours)

2

Syllabus

Cellular processes are driven by interactions between molecules that assemble into biologically active complexes.

This course focuses on the interactions between proteins and nucleic acids (DNA and RNA), exploring the molecular recognition mechanisms that govern these interactions and their broader impact on cellular processes.

We will examine a range of experimental and computational techniques used to study these interactions in vivo, in vitro, and in silico. 

The course integrates lectures with active discussions of both classical and recent studies in the field.

Together, we will critically analyze how the findings of these studies have shaped current perspectives, explore alternative interpretations, and discuss open questions, including potential experiments to address these gaps.

Active participation is essential. Students are expected to engage in discussions, build on topics covered in previous lectures, and carefully read 3–4 assigned research papers for class discussions.


Course Requirements

  • Assignments: 3 homework assignments.
  • Quizzes: 3 quizzes.
  • Attendance and Participation: Attend at least 80% of the lessons and actively participate in discussions.

Grading
40% for attendance and participation,

30% for homework (10% each)

30% for quizzes (10% each)

 


 

Learning Outcomes

Upon successful completion of this course, students should be able to:

  • Explain the fundamental principles of protein-nucleic acid interactions.

  • Evaluate experimental and computational methods for studying these interactions.

  • Analyze and interpret scientific literature on protein-DNA/RNA interactions.

Reading List

TBA

Website

N/A