Course Identification

Protein Structure and Function (PSF) I 2025-2026

Syllabus

Lecture 1 (28/10/25) DF
Introduction and Protein primary structure: the exquisite physical-chemical composition of proteins

Lecture 2 (4/11/25) DF

Protein secondary structure: helices, sheets, and beyond!

Lecture 3 (11/11/25) DF

Protein tertiary structure: folds, evolution, and introduction to structure determination

Lecture 4 (18/11/25) SL
Contemporary methods of protein structure determination

Lecture 5 (25/11/25) DF
Protein quaternary structure and the building of complex functions

Lecture 6 (2/12/25) DF
Protein thermodynamics: driving forces and energy landscapes

Lecture 7 (9/12/25) DF

Protein-protein interactions and protein regulation

Lecture 8 (16/12/25) SL

Proteins in motion: computational and experimental methods for studying protein dynamics

Lecture 9 (23/12/25) DF

Post-translational modifications and cofactors

Lecture 10 (30/12/25) SL

Enzymes

Lecture 11 (6/1/26) SL

Membrane proteins

Lecture 12 (13/1/26) SL

Protein design and engineering

Lecture 13 (20/1/26) SL

Proteins in disease: molecular mechanisms, drugs, and drug design

Upon successful completion of this course students should be able to understand why proteins fold and be familiar with the factors influencing protein folding, interaction, and function. They should be able to critically evaluate contemporary literature reporting data and analysis of protein structure determination. They should be inspired to carry out research in the fields of protein biochemistry and structural biology!