Course Identification
Transcriptional control of gene expression
Lecturers and Teaching Assistants
Prof. Rivka Dikstein, Prof. Michael Walker
Course Schedule and Location
Wednesday, 11:15 - 13:00, Wolfson Auditorium
01/11/2017
Field of Study, Course Type and Credit Points
Life Sciences: Lecture; Core; 2.50 points
Life Sciences (Systems Biology Track): Elective; Core; 2.50 points
Life Sciences (Molecular and Cellular Neuroscience Track): Elective; Core; 2.50 points
Life Sciences (Brain Sciences: Systems, Computational and Cognitive Neuroscience Track): Elective; Core; 2.50 points
Prerequisites
Basic knowledge of gene expression mechanism - level of textbook e.g. Alberts, Darnell.
Attendance and participation
Scheduled date 1
26/02/2018
Benoziyo Biochemistry Auditorium 191
Estimated Weekly Independent Workload (in hours)
Syllabus
- The transcription reaction, eukaryotic RNA polymerases and transcription initiation
- Transcription elongation and termination; Organization of transcription regulatory elements
- Transcription regulation by activators and repressors
- Regulation of transcription by signalling pathways and developmental transcription programs
- Transcriptional Dynamics
- Structure of chromatin
- Epigenetic regulation of gene expression
- Coupling of post transcription events with transcription
- Computational approaches for the analysis of gene expression
Learning Outcomes
Upon successful completion of this course students should be be able to:
- Demonstrate a good working knowledge of the key mechanistic principles underlying our current understanding of eukaryotic gene transcription.
Reading List
- Molecular Biology of the Cell - Bruce Alberts
- RNA, Life?s Indispensable Molecule - James Darnell