Course Identification

Protein Structure and Function 1
20192021

Lecturers and Teaching Assistants

Prof. Ron Diskin, Prof. Deborah Fass
N/A

Course Schedule and Location

2019
First Semester
Tuesday, 09:15 - 11:00, Schmidt, Auditorium
06/11/2018

Field of Study, Course Type and Credit Points

Chemical Sciences: Lecture; Elective; Core; 3.00 points
Chemical Sciences (Materials Science Track): Lecture; Elective; 3.00 points
Life Sciences: Lecture; Elective; Core; 3.00 points
Life Sciences (Molecular and Cellular Neuroscience Track): Lecture; Elective; Core; 3.00 points
Life Sciences (Computational and Systems Biology Track): Lecture; Elective; Core; 3.00 points
Mathematics and Computer Science (Systems Biology / Bioinformatics): Lecture; Elective; 3.00 points

Comments

On November 20th the lecture will be held at Wolfson Auditorium.

Starting January 15, the lectures will be held at Wolfson Auditorium.

Prerequisites

No

Restrictions

200

Language of Instruction

English

Attendance and participation

Obligatory

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

50%
50%

Evaluation Type

Examination

Scheduled date 1

10/02/2019
Wolfson Auditorium
1000-1200
N/A

Scheduled date 2

12/03/2019
FGS, Rm C
1000-1200
N/A

Estimated Weekly Independent Workload (in hours)

4

Syllabus

Lecture 1 (6/11/18) DF
Course introduction
Protein primary structure: physical-chemical composition of proteins

Lecture 2 (13/11/18) DF
Protein secondary structure: helices, sheets, and beyond
Secondary structure propensities and prediction

Lecture 3 (20/11/18) RD
Tertiary structure: basic folding motifs, topology

Lecture 4 (27/11/18) DF
Quaternary structure: protein oligomerization

Lecture 5 (4/12/18) DF
Quaternary structure: polymerization and protein pathologies

Lecture 6 (11/12/18) RD
Principles, practices, challenges, and recent revolutions in protein structure determination I

Lecture 7 (18/12/18) RD
Principles, practices, challenges, and recent revolutions in protein structure determination II

Lecture 8 (25/12/18) DF
Protein thermodynamics

Lecture 9 (1/1/19) RD
Protein-protein interactions

Lecture 10 (8/1/19) DF
Protein folding, conformational changes, and dynamics in protein function I

Lecture 11 (15/1/19) DF
Protein folding, conformational changes, and dynamics in protein function II

Lecture 12 (22/1/19) RD
Enzymes

Lecture 13 (29/1/19) DF
Membrane proteins

Lecture 14 (5/2/19) RD
Molecular Machineries

Learning Outcomes

Upon successful completion of this course students should be able to:

  1. Describe fundamental hierarchy of protein structure, namely primary, secondary, tertiary, and quaternary structure.
  2. Discuss how contemporary research still aims to refine our understanding of these basic concepts.
  3. Describe principles of protein thermodynamics.
  4. Demonstrate proficiency in various definitions of and approaches to the protein folding problem.
  5. Discuss spectroscopic techniques in conjunction with the aspects of protein structure they probe, and particular challenges for the study of protein folding and stability in vivo.
  6. Describe special classes of protein such as enzymes, chaperones, and membrane proteins.
  7. Design and interpret experiments in structural biology and protein biochemistry.

Reading List

N/A

Website

N/A