Course Identification
Epigenetics: From Stem Cells to Embryonic Development
Lecturers and Teaching Assistants
Dr. Yonatan Stelzer, Prof. Amos Tanay
Course Schedule and Location
Wednesday, 14:15 - 16:00, Wolfson Auditorium
07/11/2018
Field of Study, Course Type and Credit Points
Life Sciences: Seminar; Elective; 2.00 points
Life Sciences (Molecular and Cellular Neuroscience Track): Seminar; Elective; 2.00 points
Life Sciences (Computational and Systems Biology Track): Seminar; Elective; 2.00 points
Attendance and participation
Required in at least 80% of the lectures
Estimated Weekly Independent Workload (in hours)
Syllabus
The course will include lectures and seminars, given by students, on selected topics. The structure of the course will be divided into 4 main sections:
(i) Early Mammalian Development
- Pre-implantation
- Gastrulation
- Germline
- Stem Cells (Embryonic and Adults)
- Parental Imprinting
(ii) Mechanisms
- DNA methylation
- TF and the regulation of cell fate
- X and the Hox
(iii) Methods
- Single Cells
- Lineage Tracing
- Ex-vivo
- Genome engineering and mouse genetics
(iv) Controversies and Forward looking
- Transgenerational epigenetic inheritance
- Stemness
- Evolutionary origin of epigenetics
Learning Outcomes
Upon successful completion of the course students will be able to:
- Demonstrate broad familiarity with research topics and open questions in epigenetic and stem cells fields
- demonstrate an understanding of the multiple layers of epigenetic regulation during early mammalian development
- Critically assess current methodologies and important findings in the field 4. Demonstrate improved skills in critically evaluating scientific papers
Reading List
A list of recommended reading materials and papers for seminars will be provided before each lecture