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Translational vs basic research and course overview
Why epidemiology? Introduction, inter-individual variability; dirty data, descriptive epidemiology
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Principles of cancer epidemiology (Cancer burden, cancer research history, principles of cancer epidemiology (descriptive, analytical); study design: prospective & case-control studies; randomized trials)
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Biostatistics for translational cancer research-1 Hypothesis testing, Sample size, Sources of variations, confounding, biases
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Biostatistics for translational cancer research-2 Relative Risk, Odds Ratio, logistic regression, survival data, Measures of diagnostic and prognostic accuracy, sensitivity, specificity, ROC curves
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Overview of cancer prevention Primary prevention-Etiology (associations), Secondary prevention-early detection; Tertiary prevention-prognosis and survival
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Biomarkers in translational and clinical research Omics, liquid biopsy; immuno-assays and functional assays; a case study of biomarkers for lung cancer
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Analysis of Omics data Lots of information for small number of samples: False Discovery Ratio, biological pathway driven analysis
Big Data management and utilization for translational cancer research Challenges and limitations of big data analysis
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Imaging in translational research
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Cancer Screening Advantages and disadvantages in screening; biases, cost-effectivenes); Tools for screening: imaging, biomarkers;
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Cancer Drugs development – from idea to drug Phases of drug development, regulation, trialsA case study
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Targeted cancer therapies Challenges, tumor heterogeneity; drug targets; Immunotherapy; cost.
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Choosing right models for translational cancer research Animal models: human vs syngeneic, GEMMs, PDXs, humanized mouse models/non-animal alternatives (3D cultures, organoids); Including examples.
IRB@ WIS; Helsinki approvals
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Ethical considerations in translational clinical research/Helsinki declaration; stem cells; animal models
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Technology transfer at WIS- from academia to industry – success stories
'Public Trial' on a hot topic related to translational cancer research, with students acting as defense and plaintiff attorneys, witnesses, and jury.
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