Course Identification

Winter School on Drug Discovery
20192271

Lecturers and Teaching Assistants

Prof. Nir London
N/A

Course Schedule and Location

2019
First Semester
N/A
03/12/2018
07/12/2018

Field of Study, Course Type and Credit Points

Chemical Sciences: Seminar; Elective; 1.00 points
Life Sciences: Elective; 1.00 points

Comments

This is an international school - attending WIS students that participate and take an exam following the school will be entitled for credit.

Prerequisites

No

Restrictions

50

Language of Instruction

English

Attendance and participation

Obligatory

Grade Type

Pass / Fail

Grade Breakdown (in %)

100%

Evaluation Type

Examination

Scheduled date 1

17/12/2018
FGS, Rm B
1300-1400
N/A

Scheduled date 2

19/12/2018
FGS, Rm B
1300-1400
N/A

Estimated Weekly Independent Workload (in hours)

1

Syllabus

* Drug Discovery Enabled by Med. Chem.
* Treatment of lung cancer using combinations of antibodies and kinase inhibitors
* The relation between bitterness, toxicity and therapeutic potential
* Introduction to Computational Drug Design
* Data for Drug Discovery
* Discovery of Protein Translation Modulators as Therapeutic Drugs
* Image based high content analysis as a platform for drug
* Novel chemical biology tools for protein imaging and drug discovery
* Obesity, diabetes and Alzheimer's disease crosstalk: new therapeutic potential of anorexigenic neuropeptides
* The design of next generation substrate specific inhibitors targeting ECM remodeling enzyme
* Inhibiting PARP - from idea to registration
* Chemical Biology in Drug Discovery
* Chemical Probes in Target Discovery
* Biomolecular NMR in knowledge-based drug design
* XChem fragment screening and streamlined follow-up
* Covalent Drug Discovery
* How PROTACs work
* Vascular targeted photo-dynamic therapy with Tookad; The road to approved paradigm shift in cancer

* Catalysis as Key Technology for the Synthesis and Scale-up of APIs and Their Intermediates
* Design of novel enzyme inhibitors – PI4KB and nSMase2
* Role of Medchem in Drug discovery Collection of Vignettes from Personal experience
* The discovery of AZD4547

Learning Outcomes

Students taking this course will have a deeper understanding of the academic and industrial drug discovery process, and the various cutting edge techniques employed to progress it. 

Reading List

None

Website