Course Identification

The RNA world
20233111

Lecturers and Teaching Assistants

Prof. Eran Hornstein, Prof. Rotem Sorek, Prof. Igor Ulitsky, Dr. Iddo Magen
N/A

Course Schedule and Location

2023
First Semester
Tuesday, 11:15 - 13:00, Belfer, Botnar Auditorium
08/11/2022
10/02/2023

Field of Study, Course Type and Credit Points

Life Sciences: Lecture; Elective; Regular; 2.50 points
Chemical Sciences: Lecture; Elective; Regular; 2.00 points

Comments

N/A

Prerequisites

No

Restrictions

120

Language of Instruction

English

Attendance and participation

Expected and Recommended

Grade Type

Numerical (out of 100)

Grade Breakdown (in %)

100%

Evaluation Type

Examination

Scheduled date 1

12/03/2023
Ebner Auditorium
1100-1300
N/A

Scheduled date 2

03/04/2023
Ebner Auditorium
0900-1100
N/A

Estimated Weekly Independent Workload (in hours)

1

Syllabus

RNA emerges in recent years as a dominant mechanism for regulation of biological processes at all levels. The aim of this course is to explore advanced topics in RNA-based regulation. The course will discuss mechanisms such as microRNA, alternative splicing, RNA editing and nonsense mediated RNA decay. A strong focus will be put on microRNA biochemistry, target selection and developmental impact. We will also discuss small RNA based regulation in prokaryotes including riboswitches, sRNA, and CRISPR.
Rotem - alternative splicing
Rotem - NMD and editing
Rotem - intro to lincRNAs
Rotem - bacterial ncRNAs
Rotem - CRISPR
Igor - lncRNAs
Igor - lncRNAs
Igor - other ncRNAs
28-Dec Eran - miRNA intro
3-Jan Eran - miRNA biogenesis
10-Jan Eran - miRNA: development & disease (muscle, stem cells, cancer)
17-Jan Eran - biomolecular condensates 
24-Jan Eran & Ramesh Pillai - piRNA
Feb-7 miRNA mechanism of action, circRNAs, sponges, ceRNA

Learning Outcomes

Upon successful completion of this course students should be able to:

  1. Understand the multiple layers of RNA regulation including microRNAs, alternative splicing, riboswitches etc.
  2. Demonstrate proficiency in the recent literature in the filed.
  3. Incorporate RNA studies into his/her own research.

Reading List

N/A

Website

N/A